• SIREs Version: 3.0

REFERENCES

  1. 1. Henderson BR, Menotti E, Bonnard C, Kuhn LC (1994) Optimal sequence and structure of iron-responsive elements. Selection of RNA stem-loops with high affinity for iron regulatory factor. J Biol Chem 269: 17481-17489. Pubmed
  2. 2. Henderson BR, Menotti E, Kuhn LC (1996) Iron regulatory proteins 1 and 2 bind distinct sets of RNA target sequences. J Biol Chem 271: 4900-4908. Pubmed
  3. 3. Butt J, Kim HY, Basilion JP, Cohen S, Iwai K, et al. (1996) Differences in the RNA binding sites of iron regulatory proteins and potential target diversity. Proc Natl Acad Sci U S A 93: 4345-4349. Pubmed
  4. 4. Kohler SA, Menotti E, Kuhn LC (1999) Molecular cloning of mouse glycolate oxidase. High evolutionary conservation and presence of an iron-responsive element-like sequence in the mRNA. J Biol Chem 274: 2401-2407. Pubmed
  5. 5. Sanchez M, Galy B, Dandekar T, Bengert P, Vainshtein Y, et al. (2006) Iron regulation and the cell cycle: identification of an iron-responsive element in the 3'-untranslated region of human cell division cycle 14A mRNA by a refined microarray-based screening strategy. J Biol Chem 281: 22865-22874. Pubmed
  6. 6. Sanchez M, Galy B, Muckenthaler MU, Hentze MW (2007) Iron-regulatory proteins limit hypoxia-inducible factor-2alpha expression in iron deficiency. Nat Struct Mol Biol 14: 420-426. Pubmed
  7. 7. Mignone F, Grillo G, Licciulli F, Iacono M, Liuni S, et al. (2005) UTRdb and UTRsite: a collection of sequences and regulatory motifs of the untranslated regions of eukaryotic mRNAs. Nucleic Acids Res 33: D141-146. Pubmed
  8. 8. Bengert P, Dandekar T (2003) A software tool-box for analysis of regulatory RNA elements. Nucleic Acids Res 31: 3441-3445. Pubmed
  9. 9. Muckenthaler MU, Galy B, Hentze MW (2008) Systemic iron homeostasis and the iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network. Annu Rev Nutr 28: 197-213. Pubmed
  10. 10. Hentze MW, Caughman SW, Casey JL, Koeller DM, Rouault TA, et al. (1988) A model for the structure and functions of iron-responsive elements. Gene 72: 201-208. Pubmed
  11. 11. Muckenthaler M, Gray NK, Hentze MW (1998) IRP-1 binding to ferritin mRNA prevents the recruitment of the small ribosomal subunit by the cap-binding complex eIF4F. Mol Cell 2: 383-388. Pubmed
  12. 12. Binder R, Horowitz JA, Basilion JP, Koeller DM, Klausner RD, et al. (1994) Evidence that the pathway of transferrin receptor mRNA degradation involves an endonucleolytic cleavage within the 3' UTR and does not involve poly(A) tail shortening. EMBO J 13: 1969-1980. Pubmed
  13. 13. Campillos M, Cases I, Hentze MW, Sanchez M.(2010) SIRES: Searching for iron-responsive elements. Nucleic Acids Research. 13: 1969-1980.2010 Jul 1;38(Web Server). Link
  14. 14. Meehan HA, Connell GJ. (2001) The hairpin loop but not the bulged C of the iron responsive element is essential for high affinity binding to iron regulatory protein-1. Journal of Biological Chemistry:276(18):14791–6. Pubmed
  15. 15. Volz K. (2021) Conservation in the iron responsive element family.Genes: 12(9):1365. doi:10.3390/genes12091365 Pubmed
  16. 16. Luscieti S, Galy B, Gutierrez L, Reinke M, Couso J, et al. (2017) The actin-binding protein profilin 2 is a novel regulator of iron homeostasis. Blood: Oct 26;130(17):1934-1945. doi: 10.1182/blood-2016-11-754382 Pubmed
  17. 17. Sanchez M, Galy B, Schwanhaeusser B, Blake J, Bähr-Ivacevic T, Benes V, Selbach M, Muckenthaler MU, Hentze MW. (2011) Iron regulatory protein-1 and -2: transcriptome-wide definition of binding mRNAs and shaping of the cellular proteome by iron regulatory proteins. Blood. Nov 24;118(22):e168-79. doi: 10.1182/blood-2011-04-343541. Pubmed
  18. 18. Joshi R, Sanchez M. (2012) Cellular Iron Metabolism - The IRP/IRE Regulatory Network. Iron Metabolism, InTech. doi: 10.5772/34987 Pubmed

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  4. Özdöl U, Özdemir ZC, Töret E, Özen H, Bör Ö. Thrombin generation assay in platelet‐poor plasma in children with iron deficiency anemia. International Journal of Laboratory Hematology [Internet]. 2023. Link
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  13. Wang B, Thompson MS, Adkins KM. Characteristics of the Iron-responsive Element (IRE) Stems in the Untranslated Regions of Animal mRNAs. The Open Biochemistry Journal. 2021;15(1):26–37. Link
  14. Volz K. Conservation in the Iron Responsive Element Family. Genes. 2021;12(9):1365. Link